![]() However, the fundamental basis of our observation is not yet clear and needs further investigation by, e.g., cell experiments. Of note, we just recently revealed that expression of XP genes was predictive of response in two cohorts of anti-PD-1 treated melanoma patients. Remarkably, the immunological consequences of NER defects are far less explored than those of MMR and BER, although people suffering from the NER defect disease, xeroderma pigmentosum (XP), had an impressive response of their skin tumors to anti-programmed cell death-1 (PD-1) ICI in case reports. Besides MMR, there are two other pathways that repair DNA single-strand breaks (SSB): base excision repair (BER) and nucleotide excision repair (NER). food and drug administration for mismatch repair (MMR) deficient (or microsatellite instability-high) cancer. Certainly, the most prominent clinical example is the first site/tissue agnostic approval of pembrolizumab by the U.S. In the last years, the defects of different DNA repair pathways have been associated with an increased response to immune checkpoint inhibition (ICI) in cancer patients. The results of our study serve as the fundamental basis for the investigation of the immunological consequences of XPA disruption in melanoma. The better performance of the homozygous than the heterozygous mutated exon 1 cells in DNA damage repair (HCR) and post-UV-C cell survival (MTT), was associated with the expression of a novel XPA protein variant. In XPA exon 2, we generated a compound heterozygous mutated cell line ( c.206_208delTTG/c.208_209delGA p.I69_D70delinsN/p.D70Hfs*31). In XPA exon 1, we established a homozygous ( c.19delG p.A7Lfs*8) and a compound heterozygous ( c.19delG/c.19_20insG p.A7Lfs*8/p.A7Gfs*55) cell line. Based on their genetic sequence, candidates from XPA exon 1 and 2 were selected and further analyzed by immunoblotting, immunofluorescence, HCR and MTT assays. The resulting subclonal cell lines were investigated by Sanger sequencing. Therefore, we used CRISPR/Cas9 to disrupt XPA in A375 melanoma cells. The underlying mechanisms of this finding are still to be revealed. Recently, in melanoma patients, pretherapeutic XP gene expression was predictive for anti-programmed cell death-1 (PD-1) ICI response. In particular, patients with the nucleotide excision repair (NER) defect disease Xeroderma pigmentosum (XP) responded impressively well to ICI treatment. Defects in DNA repair pathways have been associated with an improved response to immune checkpoint inhibition (ICI). ![]()
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![]() ![]() You can also take it on camping trips or do as the Hoffmans and bring it home when you leave the cabin to use as a back-up generator.įor more about solar generators including the Humless, visit. Unlike a fixed generator, you can move a portable solar around to get the maximum watts of solar power. Four built-in USB ports let you charge phones, laptops, or other small electronic devices. The Humless has an integrated 1500-watt pure sine wave inverter, and comes with your choice of one, two, or three 100-watt folding solar panels. The lighter lithium battery provides more power for pound and can go longer without recharging. The upgraded Solar Generator 1000 Pro supports. Support Free Shipping To Most European Union Countries. The generator can be fully charged 1,000 times, which means it can last for a decade if used once a week. All order processing and email responses may be delayed due to holidays. ![]() ![]() The Humless 1500 1.3 kWh (100 Amp Hour) generator at this cabin weighs under 50 pounds and features a lithium battery instead of the sealed lead-acid kind found in other portable solars. BLUETTI EU: Portable Power Station, Solar Generator Kit 2+2 Years Extended Warranty For AC200P/200MAX/B230, Learn More. (Appliances are designed to run off pure sine wave power, so don’t settle for a model with modified sine wave inverter.) Up to 7 Days of Emergency and Reliable Power. Explorer 2000 Pro + 2 SolarSaga 200 2160-Watt Hour Portable Solar Generator. An integrated inverter converts DC electricity (direct current from the sun) into AC (alternating current) needed for appliances. Collect and store energy from the sun with a portable solar generator and solar panel kit. Generark Solar Generator for Homes & RVs: HomePower 2 STARTER Backup Battery Power Station & Two (2) All-Weather Portable Solar Panels. Solar generators capture power from the sun via solar panels, and store it in an internal battery. There are a number of brands on the market, so research before you buy.Ī clean source of alternative energy, “plug and play” portable solar generators are pre-configured and ready to use out of the box. Small portable solar generators can either supplement propane ones for round-the-clock power, or go solo at cabins with good solar gain and low electricity needs like this one. In stock and ready to ship The Titan Solar Generator is one of the most versatile portable solar generators on the market. They are completely silent and emit no exhaust or fumes. Unlike gas or propane models, solar generators draw power from the sun, not fuel. Solar generators are a great option for the off-grid cabin. It takes 9 hours of solar energy to have 80 power for the Explorer 1500 power station. EFFICIENCY AT YOUR FINGERTIPS: Jackerys Solarpeak Technology boosts a 30 more recharging efficiency with its MPPT solar regulartor. This web-exclusive article provides bonus info on portable solar generators for the magazine story “The Unplugged Cabin: Off-Grid in the Catskills”. The outdoor genertator is powered by solar energy, providing a green and sustainable solution for our living condition. ![]() ![]() The only thing separating you from progressing in the game is skill. It is exactly the same from the first time you play it to the 10,000th (with the slight exception of the somewhat random generation of the obstacles). The gameplay loop isnt defined by loot, microntransactions, energy, perks, abilities, or anything else of the sort. You just press try again and take another shot, all the while attempting to find that perfect zen-like feeling where your subconscious practically takes over and you fly past your previous record. Because the game is so simple, there is no need to reassess your approach, switch weapon loadouts, or even attempt a slightly different route. Obviously this is something thats present in many games, but in my opinion none handle it as elegantly and rewardingly as Super Hexagon. Almost every single time you think youve reached your skill ceiling you havent, and the only way to discover that is to keep playing. This does not just apply for the first few times you play the game, the first few hours, or even the first dozen hours. Simply put -the more you play, the better you get, but that simplification doesnt begin to do justice to just how well this concept is implemented and executed in Super Hexagon. So why did I keep banging my head against the psychedelic wall of Super Hexagon when I was clearly not making much progress? The answer is simple - I could see that I was making progress. In my experience, some of the later stages can take weeks of consistent stubbornness (probably 15 minutes a day or so) to overcome. Of the six stages in the game (three stages with a hyper version of each), the first is by far the easiest, and if you stick with it you will probably mange to beat it within a day or so (depending on how fast of a learner you are as well).Īs you progress from stage to stage, you will find yourself having to almost start over from scratch as each stage features new obstacles and shape arrangements to test your brain. Your second, third, fourth, and fiftieth attempt probably wont be much different, but if you keep at it eventually your brain will become trained enough to hit the 60 second mark, which is basically considered by the game to be beating the level. When you first play Super Hexagon you probably wont survive for more than a few seconds. The reason I continue to go back to this game day after day, time after time, is because it is as close to perfect as a game can be from a gameplay perspective, as well as the fact that the game has one of the best difficulty curves in any game Ive ever played. And no, it isnt because of the many power-ups you can obtain throughout the game, as there are none of those either. It isnt because of the ability to grind to obtain currency, as there is none. ![]() Okay, so if Super Hexagon is so simple why have I played it literally every day since its release (August 31st, 2012)? It isnt because of microtransactions, as the game doesnt have any. ![]() ![]() In my opinion the game is even simpler than something like Pac Man, to the point where the goal, controls, and scoring system are immediately apparent once you start playing. Let me be clear, Super Hexagon is an incredibly simple game. The game makes an immediate impression on you from the first time you try it thanks to its trippy and infectious soundtrack and visuals, as well as its relative simplicity. Anyway, what I really wanted to talk about is just how incredible of a game Super Hexagon is. ![]() ![]() ![]() The software can be ordered directly from TechSmith ( ). The TechSmith Camtasia software does not come with this book. Note: You will need to download the book’s data assets that have been created specifically to support this book (instructions for downloading the data assets are in the “About This Book” section at the beginning of the book). Confidence Checks to challenge your new skills.Dozens of step-by-step, hands-on activities.All of the Camtasia projects, images, audio files, and other assets needed to get started (Just download and install the free Camtasia 30-day trial from the TechSmith website and jump in!).This book will introduce you to the essential TechSmith Camtasia skills you need to get up and running with this awesome eLearning development tool as quickly as possible. You will use the powerful Camtasia Editor to add animations, voiceover audio, graphics, music, annotations, closed captions, and quizzes to a project, and much more. Your content can be hosted on a web server, Learning Management System, YouTube, Vimeo, TechSmith’s, and more.ĭuring the step-by-step lessons presented in this book, you will learn how you can include recordings of existing PowerPoint presentations or software demonstrations created directly on your computer using the Camtasia Recorder. You can Share your finished project so it can be accessed by learners using desktop computers, laptops, tablets, and other mobile devices. Using TechSmith Camtasia, you can quickly create software demonstrations, software simulations, and soft skills eLearning. To discover how TechSmith can empower your resellers to create remarkable videos and images that help share knowledge and information contact Chase Inabinet at or TechSmith’s own Kim Stagg at or Camtasia 2021: The Essentials (ISBN: 9781944607777)Ī self-paced, hands-on workbook that teaches the core TechSmith Camtasia 2021 skills! Themed callouts, colors, and a simplified interface make videos look great without the extra effort. We’ve curated a collection of high-quality, royalty-free assets (backgrounds, lower-thirds, music tracks, icons, and motion graphics) for all your customers’ video needs. This provides a crisp, polished look without the need for a professional video editor. Stunning video effectsĪpply behaviors that are perfectly designed to animate text, images, or icons. And users can edit at resolutions up to beautiful 4K, for clear video at any size. Every effect and element in a video can be dropped and edited directly in the preview window. In TechSmith Camtasia, click the Downloads button > Download more assets. Share videos with any audience on any device or video-hosting platform, including a corporate LMS, SharePoint, an existing video hosting solution, or even YouTube and Vimeo. Our drag-and-drop video editor lets a user easily add professional-quality titles, animations, music, transitions, and more. Record a screen or import camera footage and then edit videos in no time. Camtasia is easy to deploy and approachable for all levels of the organization to create interactive training videos, sales presentations, product overviews, marketing videos, and more. Camtasia gives them all the tools they need to easily make an engaging video in hours, not days. ![]() Your customers don’t have to spend thousands of dollars to outsource their videos, or spend months learning complicated systems. The best all-in-one video editor and screen recorder Make Amazing Videos and Screen Recordings with Camtasia ![]() ![]() I encourage you to purchase these through Lamplighter Books rather than Amazon, because Lamplighter is a company worth supporting! But used copies do crop up on ThriftBooks from time to time, so you might be able to save some money by purchasing through ThriftBooks. And I am so grateful to Lydia for introducing me to them. These are stories that I savored when I read them alone and that now hold all four of my daughters rapt at the table after school when we read them together. Tales of the Kingdom Trilogy is a novel trilogy written by David and Karen Mains. They’re a little dated, but in this era of ’80s nostalgia, that’s pardonable. The Tales of the Kingdom books are pricey, but they’re worth it. But know that this is a delightful set of stories, and I can’t stop thinking about them. Karens childrens-book series The Kingdom Tales Trilogy was given the Evangelical. I do not think I will summarize the plot for you, because I enjoyed diving into this series equipped only with the Lamplighter blurb and Lydia’s endorsement. For decades, Karen Mains, a prolific writer and gifted communicator. My favorite book is Tales of the Resistance. This series has the allegorical feel of both classics, and a similar knack for inviting deep truths in the side door while you’re distracted by a wonderful story. It is a joy to receive letters like this one, written on lined school tablet paper where the envelope is addressed with a pencil: Dear David and Karen Mains, My name is Calvin. In the catalog blurb, Lamplighter Books compares Tales of the Kingdom, favorably, to Pilgrim’s Progress and The Chronicles of Narnia-an ambitious comparison, certainly, but not unwarranted. ![]() Calling her down to check the mail felt like the passing of some torch. The day it arrived was the first day I found a box of books on the porch that wasn’t addressed to me. After her starring and dog-earing spree, she spent the better part of her savings on the Tales of the Kingdom trilogy. ![]() ![]() Before it hits the kitchen counter, she whisks it away, and when I find it next, there are stars in the margins by the titles she most wants to read.Īnd thus, she deserves credit for discovering today’s series. The way I used to feel about the new dELiA*s catalog: that’s how Lydia feels about the catalog from Lamplighter Books. Tale of the Kingdom, by David and Karen Mains and illustrated by Zhivko Zhelev, is the 30th anniversary edition of the story. ![]() ![]() If Gregor thinks the glass is always half full, Karin thinks the glass isn't full enough, needs to be cleaned better and could probably use something stronger than water. She then doesn't hesitate to force Anatoly to go out of the cabin or even to chop off Gregor's limbs just so she can have more of the meat.įrom her profile: " Karin will chew you up and spit you out. After The Protagonist serves meat for the first time she is very fast to develop an obsession with it. She often complains and doesn't hesitate to point out every mistake The Protagonist makes. Karin is the most stubborn and grumpy of the group. In her boss fight, however, her hair is no longer in a braid and is untamed. She also has a long, yellow, double necklace. ![]() Karin wears a long white dress with two yellow stripes at the bottom. She has long, red hair kept in a braid and green eyes. The prices in keyshops are often cheaper than in official shops, but there are certain risks involved and purchasing through unauthorized resellers won’t support the game developers directly.Karin is a tall, 27 year-old woman. Keyshops resell the game keys from undisclosed sources. ![]() ![]() Official stores retail the game keys by getting them directly through the game developer or publisher.
![]() If you're bored, kill time by reading our App Icon Generator rant. If you would like us to automate other tasks in your iOS or Android workflow, please let us know. The ability to resize a single icon means this service doubles as an app icon generator for iOS and Android apps. With our icon resizer, you can import app icons to Android Studio and Xcode in. newreleases Try IconKitchen, the successor to the Android Asset Studio, and a great new way to make highly customizable app icons for Android, iOS, and the web. To save settings in the cloud and avoid cache wipeouts, please create an account. MakeAppIcon is an icon creator that resizes all iOS icons and Android icons. We automatically save your settings in the browser. To improve this, please make a pull request. The benevolent platform bosses also want to drown developers in menial work that should be automated natively by iOS and Android platforms. Thanks, iOS and Android overlords! Supporting multiple devices and battling these amazingly talented developers is evidently not enough of a challenge. ![]() Apple also mandates retina images at 2x and 3x resolution while Android requires support for 4x (xxxhdpi), 3x (xxhdpi), 2x (xhdpi), 1.5x (hdpi), 1x (mdpi), and 0.75x (ldpi) drawables. ![]() It does not send any data to server, hence is it fully secure and your data does not leave your browser. You can generate icons that are required for iOS with a single click. Use this Hotpot service to generate icons and images for iOS, macOS, Android, Chrome, Windows, and other platforms.įor instance, iOS requires over 25 app icons, ranging in size from 16x16 to 1024x1024. Applanding page's iOS app icon generator is really easy to use. If you like this service, you'll love our AI tools. ![]() ![]() ![]() ![]() If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior. Overusing our search engine with a very large number of searches in a very short amount of time.Using a badly configured (or badly written) browser add-on for blocking content.Running a "scraper" or "downloader" program that either does not identify itself or uses fake headers to elude detection.Using a script or add-on that scans GameFAQs for box and screen images (such as an emulator front-end), while overloading our search engine.There is no official GameFAQs app, and we do not support nor have any contact with the makers of these unofficial apps. Continued use of these apps may cause your IP to be blocked indefinitely. This triggers our anti-spambot measures, which are designed to stop automated systems from flooding the site with traffic. Some unofficial phone apps appear to be using GameFAQs as a back-end, but they do not behave like a real web browser does.Using GameFAQs regularly with these browsers can cause temporary and even permanent IP blocks due to these additional requests. If you are using Maxthon or Brave as a browser, or have installed the Ghostery add-on, you should know that these programs send extra traffic to our servers for every page on the site that you browse.The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. ![]() ![]() ![]() Shiplap Cabinets in Grayscale with a Rustic Feel The spacious feel is created by the clean white cabinets and classic white sink, but the butcher’s block countertops and burnished silver drawer pull add a rustic touch. This might be the ideal template for you if you want to add some cozy farmhouse style to your small kitchen. Kitchen Cabinets in a Lightly Rustic Off-White Farmhouse Style 38 Soft-Closing And Self-Closing Hinges.26 A Drop Of Glue Keeps Knobs From Spinning.24 Four Tips For Cabinet Knob & Pull Installation.16 Cabinets in a mix of white and olive green.14 Cabinets with gold hardware in a white farmhouse style.13 White Paneled Kitchen Cabinets with an Open Front.12 White Cabinets with a Deep Distressed Finish.10 Kitchen Cabinets in a Mint Classic Style.9 Vintage Farmhouse Cabinets, Unfinished and Mixed.8 Cabinets in grayscale and white with black accents.7 Blended Tuscan and Modern Kitchen Cabinets.6 Cabinets in the farmhouse style with a 70s color twist.5 Cabinets with a lot of contrast and black accents.4 Light Gray Cabinets in a Modern Farmhouse Style.3 Kitchen Cabinets from a Victorian Farmhouse.2 Shiplap Cabinets in Grayscale with a Rustic Feel.1 Kitchen Cabinets in a Lightly Rustic Off-White Farmhouse Style.Below are 35 amazing Farmhouse kitchen cabinets that will help you turn your kitchen into the dream rustic farmhouse kitchen you’ve always wanted. Although we can’t help you build the cabinets themselves, we can motivate you to finish your home renovation. That’s why we’ve decided to provide some inspiration to help you achieve those French Country vibes in your home. To get their creative juices going, all you need is a little support. Redoing the kitchen cabinets, on the other hand, does not have to be difficult. It’s enough to make people think twice about renovating their homes. When it comes to paint, wood, and hardware, there are so many choices that it can be difficult to make a decision. It can be difficult to come up with good paint or hardware ideas on your own if you want to go a little more rustic with that ultra-popular farmhouse flair. The kitchen cabinets are the first thing people notice when they walk into the room, so you want to make sure you have the right ones to make your kitchen look fantastic while still being functional. One of the first things you, like most people, consider altering, adapting, or gutting while redoing your kitchen is your kitchen cabinets. You want your kitchen to look amazing because it is where you prepare and serve food. When it comes to home renovations, it’s all fun and games before you get to the kitchen. Can I Use Sapele Wood For Home & Kitchen Cabinets?.Can I Use Basswood For Home & Kitchen Cabinets?.Can I Use Padauk Wood For Home & Kitchen Cabinets?.Can I Use Mahogany Wood For Home & Kitchen Cabinets?.Can I Use Butternut Wood For Home & Kitchen Cabinets?.Can I Use Ash Wood For Home & Kitchen Cabinets?. ![]()
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